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KMID : 1134820000290040676
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Journal of the Korean Society of Food Science and Nutrition
2000 Volume.29 No. 4 p.676 ~ p.682
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Effect of Dandelion Leaf Extracts on Lipid Metabolism in Rats Fed High Cholesterol Diet
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Cho Soo-Yeul
Park Ji-Yoon
Oh Yeon-Jin
Jang Joo-Yeun
Park Eun-Mi
Kim Myung-Joo
Kim Kwang-Soo
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Abstract
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The effect of dandelion leaf extracts on lipid metabolism was investigated in high cholesterol-fed rats. Four groups of rats were given a high cholesterol diet containing 10 g cholesterol/kg and 2.5 g sodium cholate/kg for 6 weeks. The control group received without dandelion leaf extracts and the other three groups received with one of dandelion leaf extracts (water, ethyl acetate, ether), respectively. Weight gain and feed intake were significantly higher in water group than control group. Serum triglyceride, total cholesterol, cholesteryl ester, chylomicron and VLDL-cholesterol concentrations were lower, whereas HDL-cholesterol and phospholipid concentrations were significantly higher in dandelion leaf extract supplemented-groups than control group. Dandelion extract increased HDL-C/total-C ratio and lowered atherogenic index. Hepatic triglyceride, total cholesterol, free cholesterol and cholesteryl ester concentrations lowered in dandelion leaf extract groups compared to control group. Especially, hepatic triglyceride and free cholesterol levels were lower in ethyl acetate extract group than in water and ether extract groups. Dandelion leaf extract supplements did not affect hepatic phospholipid cencentration. Hepatic HMG-CoA reductase activity was significantly lower in water extract group than the others. ACAT activity was significantly decreased by dandelion extract supplements.
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KEYWORD
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cholesterol, dandelion leaf extract, lipid metabolism
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